Does Vitamin B17 Exist?

Does Vitamin B17 Exist? If So, is it Effective in Preventing Tumors

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Does Vitamin B17 Exist?

Overview:

There is much controversy in the medical community against two things, whether Vitamin B17 exists in the first place, and second whether it is able to be considered an effective way to prevent or inhibit the growth of tumors in patients suffering from them. We found it is quite complicated to get a finite answer to the answer of both of these questions but we will report what we did find.

Terms of interest:
Vitamin B17 | Amygdalin | Laetrile

Claims:

Amygdalin

Vitamin B17 refers to a compound known as Amygdalin. Amygdalin is naturally occurring cyanogenic glycoside compound present in fruits and seeds of fruits like apricot, peaches and bitter almonds and it was considered as a vitamin and was used for cancer treatment in late 1950s. Eating amygdalin will cause cyanide poison as amygdalin molecule has nitrile group and could be released as cyanide anion due to the action of beta-glucosidase in human body. Laetrile is a man made synthetic compound from natural amygdalin and was also used for anticancer treatment during 1970s

Laetrile

First synthesized by Krebs and termed as vitamin B17, laetrile is an acronym for the terms laevorotatory and mandelonitrile. Initially utilized as an alternative cancer therapy in Russia and then in the USA, around 1920s, it was patented by the USA as D-mandelonitrile-β-glucuronide. It is also popular in Mexico but, the compound used is D-mandelonitrile-β-gentiobioside (has two glucose molecules combined through hydroxyl positions 1 and 6). Laetrile therapy is usually taken in combination with other CAM proponents, like diet, urine, metabolic and oral therapy, β-glucuronidase injections and intake of fruit seeds. Laetrile, unlike amygdalin, has only one glucose molecule. It has 6% cyanide by weight. If eaten with foods that have β-glucosidase, combined with gut-flora composition, it leads to cyanide toxicity which can occur in three stages.

Studies Showing Positive Results:

Conflicting Finds:

Not shockingly, most of the controversy that surrounded the use of this substance as a means of cancer treatment was sprouted during the late 1970’s – 1990’s. Many of the claims from the mid 1970’s tended to focus on the “toxicity” of the use of these substances when ingested orally. Although, many of these claims seem to have not been properly investigated, but rather seized on as a means for pursing the FDA to outlaw the use of both Amygdalin and Laetrile. The FDA did begin to move to make utilizing these illegal but found difficulty when many cases were brought to state supreme courts. Many doctors called “quack” while many supported the usage. Although when clinical trials were requested, they continued to choose not to citing “toxicity,” despite many claims of successful results otherwise.

Its funny as we tend to see a pattern in our research of “falling in line” with a general opinion despite actual testing or research being done. Oddly enough grant funding for this substance doesn’t seem to run to the top of the list as many studies done on it have not been funded externally. We find it odd that the results from independent research tend to show highly positive results, while those funded by grants from medical funding foundations tend to show the opposite. Seems like there might be some NDA contracts and hush money at play here, but that is just speculation from the results we have found.

Summary of Study June 2023

A study that was published in June of 2023 titled, “Antioxidant, Anti-Inflammatory, and Anti-Cancer Properties of Amygdalin Extracted from Three Cassava Varieties Cultivated in Benin,” showed some interesting results in the study of this substance.

The summary of which was as follows:

“The study evaluated the in vitro and in vivo biological activities of amygdalin extracts from the plant. The results revealed that cassava varieties grown in Benin possess remarkable antioxidant activities and anti-inflammatory properties similar to those of non-steroidal anti-inflammatory drugs (NSAIDs). In addition, amygdalin extracts from BEN cassava leaves had anticancer activities in cancer-prone Wistar rats. This molecule effectively prevents and cures cancer by inhibiting the proliferation of cancer cells induced by DMH, which is confirmed by biochemical analysis of blood samples and histological examination.

Indeed, amygdalin, a molecule known for its numerous pharmacological properties, was quantified in cassava organs and derivatives. The results revealed the presence of this molecule in all samples but at variable levels. The leaves of the different cassava varieties and the Agbeli derivative showed a higher level of amygdalin. The anticancer power of the plant is due to the presence of a high level of amygdalin in its leaves.”

Document:

Summary:

It seems the controversial nature of the agent at hand makes it relatively difficult to ascertain final answers to our original two questions.

In a non-official sense it seems that Vitamin B17 does in fact exist and has shown evidence in the past and recently to be effective in causing anti-tumor effects, although the natural version found in apricot seeds is acclaimed to be converted in the gut by gut bacteria to cyanide. Although we have found conflicting evidence in results to this being true, one person we spoke with claimed they eat 10 apricot seeds everyday and have no negative effects that would he would consider as “toxic.”

So it seems that there is something to the Vitamin B17 story, although we do not suggest utilizing this as a method for treating any tumor related disease as the medical evidence is too conflicting. It is for you to do your own research and come to a conclusion yourself using your best judgement.
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